• Ricerca Corrente (2018-2021) Ruolo dei membri della famiglia p53 e metabolismo cellulare nella prevenzione, formazione e terapia dei tumori epiteliali L’obiettivo generale di questo progetto di ricerca è l’identificazione di nuovi circuiti molecolari attivati dai fattori di trascrizione appartenenti alla famiglia p53 / p63 / p73 e la comprensione dei meccanismi genetici ed epigenetici associati ai membri di questa famiglia nei tumori epiteliali, concentrandosi anche sulla prevenzione e terapia.
• Progetto di Grande Rilevanza MAECI (2018-2021) Il ruolo della famiglia di p53 nel rimodellamento osseo e nello sviluppo dell’osteosarcoma Progetto cofinanziato da Italian Ministry of Foreign Affairs and International Cooperation (MAECI). L’obiettivo generale del progetto è lo studio del ruolo dei fattori di trascrizione appartenenti alla famiglia p53 / p63 / p73 nell’osteogenesi e nello sviluppo di osteosarcoma e metastasi ossee utilizzando animali transgenici.

• Oncogene. 2019 Mar;38(10):1625-1638. doi: 10.1038/s41388-018-0509-4. Epub 2018 Oct 18.
• Cell Death Differ. 2020 Jul 21. doi: 10.1038/s41418-020-0590-4.
• Nat Commun. 2021 Jan 15;12(1):383. doi: 10.1038/s41467-020-20669-0

Pubblicazioni

• 2022 Dec 16 - Science advances - Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms.
• 2021 Nov - Cell cycle (Georgetown, Tex.) - TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin.
• 2021 Jan 15 - Nature communications - The p63 C-terminus is essential for murine oocyte integrity.
• 2021 Jan - Cell death and differentiation - Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
• 2020 Feb - Cell cycle (Georgetown, Tex.) - Skin immunity and its dysregulation in atopic dermatitis, hidradenitis suppurativa and vitiligo.
• 2020 Feb - Molecular oncology - ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
• 2019 Nov 17 - International journal of molecular sciences - p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer.
• 2019 Oct 1 - European journal of dermatology : EJD - Transglutaminase 3 is expressed in basal cell carcinoma of the skin.
• 2019 Oct - Cell cycle (Georgetown, Tex.) - Skin immunity and its dysregulation in psoriasis.
• 2019 May 31 - International journal of molecular sciences - p63 at the Crossroads between Stemness and Metastasis in Breast Cancer.
• 2019 May - Molecular oncology - ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment.
• 2018 Dec 28 - Aging - ΔNp63 promotes IGF1 signalling through IRS1 in squamous cell carcinoma.
• 2018 Nov 16 - Aging - ZNF185 is a p53 target gene following DNA damage.
• 2019 Mar - Oncogene - ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.
• 2018 May 5 - Biochemical and biophysical research communications - Kruppel-like factor 4 regulates keratinocyte senescence.
• 2018 Mar 15 - The Biochemical journal - Metabolic profiling of visceral adipose tissue from obese subjects with or without metabolic syndrome.
• 2018 Mar - Cell death and differentiation - Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
• 2018 Jan 24 - Oncogenesis - The hypoxic tumour microenvironment.
• 2018 - Cell cycle (Georgetown, Tex.) - Integrin-β4 is a novel transcriptional target of TAp73.
• 2018 Apr - Molecular neurobiology - p73 Regulates Primary Cortical Neuron Metabolism: a Global Metabolic Profile.
• 2017 Jan 15 - Biochemical and biophysical research communications - Metabolic pathways regulated by p63.
• 2017 Jan 31 - Oncotarget - Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.
• 2016 Oct - Mechanisms of ageing and development - Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases.
• 2017 May 30 - Oncotarget - Ultraconserved long non-coding RNA uc.63 in breast cancer.
• 2016 May 24 - Oncotarget - Metabolic pathways regulated by TAp73 in response to oxidative stress.
• 2016 May 17 - Oncotarget - Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis.
• 2015 Dec - Aging - DNA repair and aging: the impact of the p53 family.
• 2015 - Oncoscience - ßNp63 controls cellular redox status.
• 2015 Nov 13 - Biochemical and biophysical research communications - Amino-terminal residues of ΔNp63, mutated in ectodermal dysplasia, are required for its transcriptional activity.
• 2015 Apr - Aging - Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients.
• 2015 - Cell cycle (Georgetown, Tex.) - GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.
• 2015 Aug 3 - Cell cycle (Georgetown, Tex.) - TAp73 transcriptionally represses BNIP3 expression.
• 2014 Nov-Dec - European journal of dermatology : EJD - Absence of filaggrin mutation in a patient affected by pachyonychia congenita and mild atopic dermatitis.
• 2014 Mar 15 - Oncotarget - p63 transcriptionally regulates the expression of matrix metallopeptidase 13.
• 2013 Nov 15 - Cell cycle (Georgetown, Tex.) - GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.
• 2012 Nov - Aging - MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix.
• 2012 Dec 15 - Cell cycle (Georgetown, Tex.) - p63 the guardian of human reproduction.
• 2012 Dec 1 - Cell cycle (Georgetown, Tex.) - Tissue-specific expression of p73 C-terminal isoforms in mice.
• 2005 Aug - Cell cycle (Georgetown, Tex.) - Gerry Melino.