As a Post-Doc before, and senior researcher later, at the IDI-IRCCS Experimental Immunology Laboratory I have carried out a series of research programs focused on understanding the cellular and molecular mechanisms underlying immune-mediated skin diseases, in particular the psoriasis and atopic dermatitis. Over the years, my scientific interest has aimed at defining the contribution of keratinocytes, fibroblasts and endothelial cells in the pathogenic mechanisms of psoriasis and other skin diseases. Currently, my scientific commitment is particularly focused on translational studies focused on the identification of molecular and genetic biomarkers in psoriasis patients useful for improving the responder rate to biologics and reducing the risk of side effects related to the use of inappropriate biologics. At the same time, I coordinate the scientific activities of a Post Doc, on a project concerning the role of the PI3K / AKT molecular axis in the senescence and inflammatory responses of resident skin cells of patients with plaque psoriasis, and the impact of its pharmacological inhibition as a possible therapeutic intervention.